1. Get a perimeter player who can do PnR. 2. Get a PF who can hit from outside. In summary, you need other offensive weapons to beat any scheme targeting one offensive player. That's actually pretty simple. Put the burden on the GM.
A/k/a the pick and roll, which in theory should be simple to defend. Yet for some reason, in the NBA, we see it remains an effective offensive tool.
There needs to be certain variable for fronting to work. Great ball pressure and a stagnant offense are a couple. Notice shaq never got fronted? He was to big and athletic, plus the triangle is a motion offense. The knicks in 94 fronted dream with some success because of the derek harper ball pressure. Hakeem was just so good at pinning guys. The rockets bogged down a lot in the 4th because of the fronting and offensive stagnation. Its hard to front if you have guys who can get to the rim. Oh yeah, lebron is that great of a defender.