They are all meh. You really just have to go thru various drugs to see which one you have the least side effects with. My ex has psoriatic arthritis and they are all extremely expensive and so so on the effectiveness. The only treatments that might have some promise are nowhere near going to market yet. Maybe ask your doctor about some of the older treatments to see how they work for you. They are cheaper and not as hard on your body. They are basically drugs that were used for people that had organ transplants. Some are available for sale at good rates in Canadian pharmacies online.