http://games.yahoo.com/blogs/plugged-in/online-gamers-crack-aids-enzyme-puzzle-161920724.html Online gamers have achieved a feat beyond the realm of Second Life or Dungeons and Dragons: they have deciphered the structure of an enzyme of an AIDS-like virus that had thwarted scientists for a decade. The exploit is published on Sunday in the journal Nature Structural & Molecular Biology, where -- exceptionally in scientific publishing -- both gamers and researchers are honoured as co-authors. Their target was a monomeric protease enzyme, a cutting agent in the complex molecular tailoring of retroviruses, a family that includes HIV. Figuring out the structure of proteins is vital for understanding the causes of many diseases and developing drugs to block them. But a microscope gives only a flat image of what to the outsider looks like a plate of one-dimensional scrunched-up spaghetti. Pharmacologists, though, need a 3-D picture that "unfolds" the molecule and rotates it in order to reveal potential targets for drugs. This is where Foldit comes in. Developed in 2008 by the University of Washington, it is a fun-for-purpose video game in which gamers, divided into competing groups, compete to unfold chains of amino acids -- the building blocks of proteins -- using a set of online tools. To the astonishment of the scientists, the gamers produced an accurate model of the enzyme in just three weeks. Cracking the enzyme "provides new insights for the design of antiretroviral drugs," says the study, referring to the lifeline medication against the human immunodeficiency virus (HIV). It is believed to be the first time that gamers have resolved a long-standing scientific problem. "We wanted to see if human intuition could succeed where automated methods had failed," Firas Khatib of the university's biochemistry lab said in a press release. "The ingenuity of game players is a formidable force that, if properly directed, can be used to solve a wide range of scientific problems." One of Foldit's creators, Seth Cooper, explained why gamers had succeeded where computers had failed. "People have spatial reasoning skills, something computers are not yet good at," he said. "Games provide a framework for bringing together the strengths of computers and humans. The results in this week's paper show that gaming, science and computation can be combined to make advances that were not possible before."
I saw this on MSN a couple of days ago, it is really cool stuff.....community scientific study. BRILLIANT ! DD
i just signed up for foldit because of my biochem lab. Its is pretty fun if you like puzzles and 3-D. it feels like solving a complex rubics cube. http://fold.it/portal/
1. Become a Gamer 2. Discover Structure of Elusive Enzyme 3. ?? 4. Profit! Seriously though, this is awesome, I can see it now, a movie in about 5 years starring Bruce Willis and some gamer with the secret to curing whatever disease is popular at the moment, Bruce is trying to save the gamer from Euro-Bio-Terrorists! Woohoo!! Profit!!
Stuff like this is awesome. Along these lines, I run a Folding@Home client on my desktop, another on on my GPU, and also run a IBM World Community Grid/BOINC client on my desktop and laptop. If you've got spare cycles, you should donate them to research like this. Distributed computing can aid in some awesome causes and this story is proof.
Wasn't this part of the premise in StarGate Universe? The guy solves a problem in a game??? Rocket River
[rquoter]Online gamers crack AIDS enzyme puzzle[/rquoter]Pffft. I just shot my 200th pigeon on GTA to get to 100%. Little f---er was hiding on top of a bridge. Clearly, I feel I've made the greater accomplishment.
