Tie between Dreyfus and Danson. Danson was a fairly key component of Curb Your Enthusiasm and between Becker and Good Place showed really good range. Watching Ellie was very forgettable, however Drefyus has two separate all-time great roles and Old Christine got her some Emmy noms. I'm old enough to remember and have gotten the "strange town in Vermont" joke and my parents freaking the f out when he said it, but I guess I'll have to check out the original "Bob Newhart Show" to appreciate it.
