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COVID-19 (coronavirus disease)/SARS-CoV-2 virus

Discussion in 'BBS Hangout' started by tinman, Jan 22, 2020.

  1. CCorn

    CCorn Member

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    Opposite clientele
     
  2. daywalker02

    daywalker02 Easter Egg Hunter - Tell me why? نحن عائلة

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  3. robbie380

    robbie380 ლ(▀̿Ĺ̯▀̿ ̿ლ)
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  4. daywalker02

    daywalker02 Easter Egg Hunter - Tell me why? نحن عائلة

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    So could other nations.
     
  5. Major

    Major Member

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    You do know that GreatGameIndia is a consipiracy theorist website that basically got famous with covid fake news, right? If you trust them, you also should accept that they state that there's no evidence the vaccines prevent severe illness and other such fun things. Prior to Covid, there were a niche site that just trafficked in endless random conspiracy theories, but since last January, they went 100% covid because they found gullible people willing to repost their content and found it was way more profitable.
     
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  6. txtony

    txtony Member

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  7. hooroo

    hooroo Member

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  8. robbie380

    robbie380 ლ(▀̿Ĺ̯▀̿ ̿ლ)
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    Looks like the Indian variant is doubling in the US about every 2 weeks or so.

    https://covid.cdc.gov/covid-data-tracker/#variant-proportions

    It's the B 1.617.2 variant on that list. As of the last report for the week ending 5/22 it was about 2.5% of the reported cases. So that means it should be up to about 5% by now. Based on the UK it should take over as the dominant strain in about 8 weeks or so and we should see cases tick up a good bit in the unvaccinated areas. UK cases are up about 150% since bottoming out and the Indian strain taking over and their overall vaccination rates roughly match ours.
     
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  9. rocketsjudoka

    rocketsjudoka Contributing Member

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    Posting this here as I don't think it's controversial enough to merit the D&D thread.
    https://www.nytimes.com/2021/06/10/...l?action=click&module=Opinion&pgtype=Homepage
    The Vaccines We Have Are Good. But They Could Be So Much Better.

    Soon after the novel coronavirus emerged, its genome was sequenced and vaccines were developed at, yes, warp speed. These are all herculean tasks that deserve praise. But America’s achievement stops there. The initial vaccine strategy was reactive and tactical, not decisive and strategic. While it prioritized getting safe, effective vaccines into bodies as quickly as possible, it did not consider how to prevent variants or subsequent waves of the virus.

    All coronaviruses produce variants, and as with prior coronavirus outbreaks, variants of SARS-CoV-2 emerged as the virus spread from Wuhan, China, across the planet. The next danger is the further evolution of variants that can overcome the immunity provided by existing Covid-19 vaccines and prior infections.

    The second generation of Covid-19 vaccines, which are now in development as booster shots, is aimed at known variants, but they are not designed with future variants in mind. This is “whack-a-mole” vaccine development, an inefficient and costly approach that chases yesterday’s virus. What we need is “kill shot” immunity, which would protect people against all current and future variants and bring an end to the pandemic.

    It is possible to make a vaccine like this — if scientists closely study the patterns of how viruses mutate, and design vaccines for the viruses that we’re about to face, not just the ones we have now. This approach is especially important considering the number of ways viruses can emerge in humans, including from natural spillover (when a virus spreads from one species to another) or an accident in a virus research laboratory (“lab leak”) — both scenarios that are, appropriately, the subject of serious investigation.

    Whatever the results of those inquiries, the United States must use this pandemic to ensure that emergency vaccine development can address all possibilities.

    One approach is to predict which variants are most likely to occur in a circulating virus and prepare to defeat them in advance using pre-designed vaccines. This might seem futuristic, but the capability already exists.

    The ability to predict and counter pathogens emerging naturally, as well as genetically altered ones released from unregulated laboratories, was first developed by the U.S. government over a decade ago. In 2008, while working at the Defense Advanced Research Projects Agency, also known as Darpa, our team, led by Dr. Callahan, became alarmed by a series of bird flu outbreaks in humans associated with several foreign poultry vaccine companies.

    We were particularly concerned that well-intentioned but unregulated virus research in foreign laboratories could produce viruses that were highly infectious and capable of spreading rapidly in human populations. Between 2008 and 2016, Darpa developed a program called Prophecy to study the evolution of viruses to predict mutations and develop vaccines. The agency combined it with an alert network run by doctors working in at least seven hospitals around the world, including in places such as Singapore; Jakarta, Indonesia; and Hong Kong.

    Here’s how Prophecy worked: First, researchers studied the genome of a dangerous virus to identify areas where the virus can mutate without destroying its ability to reproduce. An overwhelming majority of mutations make a virus weaker, so most mutations can be ignored. Second, scientists used computer models to test the remaining mutated viruses and simulate all possible changes in surface proteins, which are important for a virus’s ability to infect. Scientists then designed antibodies on the computer to target these proteins and help the body recognize the virus and fight it off. By working with our research partners, we could confirm our predictions by sequencing the newest variants obtained from patients around the world. Scientists can further adjust the designer vaccine or antibody based on immunity observed among people who survived the infection.

    In addition to strengthening global health and health security, technologies and processes developed under Prophecy were instrumental in helping pharmaceutical companies make experimental vaccines and antibodies more rapidly to treat cancers that evaded the patient’s immune system, and drugs that would prevent emergence of antibiotic-resistant microbes.

    Unfortunately, the changes in U.S. political leadership in 2016 as well as budget changes led to the demise of research collaborations in nine countries, including China, Russia, Indonesia and Nigeria.

    The Biden administration’s re-engagement in global health signals an opportunity to restart Prophecy or a similar program.

    As the United States begins month 18 of the pandemic, the nation should carefully reconsider the next steps in vaccine development. We need to restore foreign research collaborations and re-establish surveillance at international hot spots where animal-to-human infections commonly occur, in China and other countries. Second, the United States must resume relationships with foreign laboratories that work with dangerous pathogens to ensure safe, secure and ethical best practices. These collaborations can be incentivized by sharing technologies such as mRNA vaccines. Third, Prophecy and similar tools need to be updated to better assess whether a virus is natural or engineered. Determining the origin of a virus allows those in charge to put in place controls to reduce the frequency and severity of future pandemics.

    While Prophecy’s first act was accurate prediction of pathogen evolution, it was the program’s second act that best serves us now: the ability to anticipate viral mutations before they occur and to counter the mutations using vaccines. These kinds of vaccines are already being studied in advanced clinical trials to prevent recurrence of drug-resistant cancers and to produce a universal influenza vaccine. Bringing these technologies to the fight against coronavirus variants could help end the current pandemic and prevent the next one. The nation should move quickly.

    Michael V. Callahan is a former Covid-19 special adviser to the assistant secretary for public health preparedness at the Department of Health and Human Services, and was incident commander for nine international highly dangerous pathogen outbreaks. He is director of Clinical Translation at the Vaccine and Immunotherapy Center at Massachusetts General Hospital. Mark C. Poznansky is an infectious diseases physician and director of the Vaccine and Immunotherapy Center at Massachusetts General Hospital and an associate professor at Harvard Medical School.
     
  10. Invisible Fan

    Invisible Fan Insider Newsletter™ 2X Diamond Member

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    I hate titles that piss on success with promises of even better success..."a more perfect success." :rolleyes::rolleyes::rolleyes: Dude is calling for even more frankenstein studies at foreign locations, which is the heart of the labber controversy.

    I get that it's eye catching, but give me a break...
     
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  11. Invisible Fan

    Invisible Fan Insider Newsletter™ 2X Diamond Member

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  12. rocketsjudoka

    rocketsjudoka Contributing Member

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    They address that specifically:
    "We were particularly concerned that well-intentioned but unregulated virus research in foreign laboratories could produce viruses that were highly infectious and capable of spreading rapidly in human populations. Between 2008 and 2016, Darpa developed a program called Prophecy to study the evolution of viruses to predict mutations and develop vaccines. The agency combined it with an alert network run by doctors working in at least seven hospitals around the world, including in places such as Singapore; Jakarta, Indonesia; and Hong Kong."

    The program they are advocating would provide more control and transparency on what happens in foreign labs.
     
  13. robbie380

    robbie380 ლ(▀̿Ĺ̯▀̿ ̿ლ)
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    The primary issue with the vaccines in my eyes is their side effects and lack of research relating to various people with pre-existing conditions (autoimmune diseases seem to be a significant one). The side effects are very common and can be very strong. There is a sliding scale based on age and health where the vaccines produce a greater injury rate than covid does. The conspiracy theorist anti covid vax people get a lot of attention, but based on the effects of the vaccine compared to the effects of covid you can have a rational minded younger person decide not to get vaccinated or have a parent make a completely rational decision not to vaccinate their child.

    We can't be in denial about the side effects of these vaccines relative to other common vaccines and relative to the actual virus it is supposed to be protecting us against. I think it is disappointing that this has become practically a taboo topic for some.

    The next generation of covid vaccines needs to have dramatic reduction in side effects if we are to expect more people to take it.
     

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