Doubt it will happen but that would be awesome. Jamarcus might actually lose some weight if he gets locked in the electrical closet.
People always "that's why the NFL doesn't do that" on all sorts of things, but the reality is that the college game is always ahead of the NFL. Everything from the Wildcat to the running mostly out of shotgun to pass-happy offenses in general were perfected at the college level before moving to the NFL. Not at all saying that would happen with Leach's offense in particular, but the whole "they don't run that in the NFL" is mostly just a result of the NFL being full of conservative copycat coordinators who don't tend to innovate all that much. At the college level, you have a lot more creativity (and, to be fair, a lot more teams that can try and experiment).
And it is a microcosm of the pressure and expectations that come with being a newly hired coach. Nobody dares to venture outside of comfort zones when you have 2 seasons tops to show your worth. NFL = Not For Long. When you look at Miami, you had a team coming off a dismal 1-15 season with nothing to lose, and suddenly the Wildcat becomes somewhat of an experiment that ends up paying dividends. In college football you've got guys with 3-4 seasons at least in programs to get a team built up and implement a specific offense that maximizes the talent brought it. Rich Rodriguez recruits Steve Slaton and Pat White, so it makes sense to run the zone read. In that aspect personnel is always an issue for an NFL coach because most of the time you're inheriting somebody else's mess. I seriously doubt Leach is going to line up 5 Wide and throw the ball 75% of the time if he ends up in the NFL, but there are definitely questions as to whether or not he'd really be able to compete with the dismal personnel the Raiders keep trotting out on the field on the offensive side of the ball.
I actually don't see a whole lot of what Leach does on offense that is different from the old run and shoot (other than the wide line splits), he simply runs it out of more/different formations. According to a Michael Lewis profile from the NYT a few years back, he rarely has more than 15-20 individual plays for a single game, they just come from different looks.