mar1juana usage links to testicular cancer

Bad news for brothers that like to get high...

http://news.bbc.co.uk/2/hi/health/7869709.stm

Frequent or long-term mar1juana use may raise a man's risk of testicular cancer, American research suggests.

The study of 369 men, published in the journal Cancer, found being a regular mar1juana user doubled the risk compared to those who never smoked it.

The results suggest that it may be linked to the most aggressive form of the cancer.

A spokesman for Cancer Research UK said that no previous studies had found a link between mar1juana and the disease.

Testicular cancer is one of the most common cancers in younger men, with approximately 2,000 new cases each year in the UK.

Incidence in Europe and North America is far higher than in some other parts of the world, and has been rising steadily for no apparent reason.

Known risk factors for the cancer include previous injuries to the testicles, a family history of the disease, or suffering from undescended testicles as a young child.

The study from scientists at the Fred Hutchinson Cancer Research Center in Seattle is the first to look specifically at mar1juana use in relation to the disease.

They studied 369 men aged 18 to 44, who had been diagnosed with testicular cancer, and quizzed them about mar1juana use.

Their replies were compared to those from almost 1,000 apparently healthy control subjects.

Even after adjusting the figures to take account of the other known risk factors, mar1juana use remained a clear risk factor for testicular cancer.

Just being a mar1juana smoker seemed to carry a 70% extra risk, while those who smoked it regularly, or had smoked from an early age, had twice the risk compared to those who had never smoked it.

A connection was made to nonseminoma, a fast-growing form of testicular cancer which accounts for approximately 40% of all cases, and tends to strike younger.

Puberty chance

Dr Janet Daling, one of the authors, said that puberty might be a "window of opportunity" during which boys were more vulnerable to environmental factors such as the chemicals in mar1juana.

"This is consistent with the study's findings that the elevated risk of nonseminoma-type testicular cancer in particular was associated with mar1juana use prior to 18," she said.

Another research, Dr Stephen Schwartz, said: "What young men should know is first, we know very little about the long-term health consequences of mar1juana smoking, especially heavy mar1juana smoking, and second, our study provides some evidence that testicular cancer could be one adverse consequence."

The next step, he said, would be to look more closely at cells in the testicles to see if any of them had receptors set up to respond to cannabis chemicals.

Henry Scowcroft, from Cancer Research UK, said: "As the researchers themselves point out, this is the first inkling that there is any association between chronic mar1juana use and testicular cancer.

"But the researchers only interviewed a relatively small number of men.

"So before we can reach any firm conclusions about whether this is a cause-and-effect relationship, rather than a statistical blip, the result needs to be replicated in a much larger study."