Aisle. Gives me more shoulder room and I can take a piss whenever I want. The only draw back is that the flight attendant bumps me sometimes.
Short flight: Window Long flight: Aisle You completely control your own destiny with an aisle seat. But privacy is highest in a window seat. On short flights, give me the window so I can do what I want and not be bugged by someone needing to use the restroom or my arm/shoulder getting hit by people walking the aisle. On long flights, give me the aisle so I can get up and stretch and use the restroom whenever I feel like it without having to ask anybody to wake up or move out of the way.
I like aisle because when I fart I can tilt towards that way. If your in a window seat you're pretty much owned.
Aisle ... I've actually given up a Window seat for a middle seat because I get very Claustrophobic at the Window with 2 people between me and the aisle where I can get up and walk around. I've gotten to the point where I don't even want to fly unless I have an aisle.
Definitely aisle. There's usually not too much to see out the window (loses it's appeal after a few minutes), and I can nap just fine on the aisle. The added legroom is far more beneficial for me.
Doesn't matter if I'm flying first class. If it's coach it better be aisle. That way I can kick my legs out a little bit. The worst is the middle being stuck between two fatties.