Any 2-player combination of Chris Paul, LeBron James, and Dwight Howard. It's hard to choose what the best one would be.
In the Olympics Lebron and Wade were pure devastation NBA, I'd like to see Chris Paul and Dwight Howard for the classic big-small pairing. Look what Paul did for Tyson Chandler. Itd be like modern day Cousy & Russell, controlling the glass and the break.
If you're talking about best two duo that will give u the best chance of wins, then i would say chris paul and dwight howard. You just have to include chris paul in there. On the other hand if you're talking about the most formidable duo, meaning players you least want to play against, then it'll be lebron and kobe.