Laguerta has pretty much set up a date with Dexter and his table, at least as soon as Dexter finds out she's on his trail...
Sirko will probably set up some death scenario where Dexter will have to choose whether to save Deb or Hannah. He will save Deb and she will be in love with him still. LaGuerta will keep poking around, but Dexter can't kill her because she doesn't fit the code.
LaGuerta should die, though. She's due. Just doesn't add much to the show. Let Sirko or Hannah kill her or something. Or even better - Deb.
I don't see how she can die unless Dexter is somehow involved. A random lucky death is pretty far fetched even for this show. Deb taking her out would be the most intriguing scenario.
Which is why it in fact will happen. Sirko kills Hannah, Dexter kills Sirko, Deb kills LaGuerta. It makes too much sense not to happen.
I think Deb will die at the end of this season. I think her character has nothing more to give because i don't think the incestous relationship is gonna happen. I think she will die at the end of this season and next season she will take over the fathers role in Dexter's head (appear only in Dexter's head). I hope Hannah doesn't die because i actually like her character but man I can't wait for LaGuerta to die but I think that will happen next season.
I think the most obvious way to go is with Sirko killing Laguerta. She is going to start snooping around Dex's life and will probably run into a confrontation between him and Sirko. He kills her and wipes out that story line. I dont think the Deb/Dex thing is that weird. Didn't we see this coming eventually? It was awkward, but wasn't that the point? They aren't just going to make out and live happily ever after.
Funny fact, the last episode of this season is titled "Surprise, Motherf*****!" Do I see a Doakes spirit return?