[Yahoo] A 47-year-old man kept getting drunk from alcohol produced in his own gut. Doctors cured him

this thread is an antidote to @Carl Herrera threads

https://news.yahoo.com/47-old-man-kept-getting-210000238.html

A 47-year-old man kept getting drunk from alcohol produced in his own gut. Doctors cured him with a poop transplant.

glandsverk@businessinsider.com (GabLandsverk)

INSIDER•August 17, 2020

• Auto-brewery syndrome is a rare illness where a person's body produces alcohol inside their gut, which can lead to drunkenness without consuming alcohol.
  
  
• Sometimes known as gut fermentation syndrome, it's caused by an imbalance of bacteria and an overgrowth of fungus in the digestive system.
  
  
• In a case study, doctors successfully treated a 47-year-old man with auto-brewery syndrome with a fecal transplant after other treatments, like a low-carb diet and anti-fungal medications, failed to help.

After undergoing a course of antibiotics, a 47-year old man noticed he was feeling drunk at seemingly random intervals throughout the day — even without consuming alcohol.

This rare condition, known as auto-brewery syndrome, occurs when the body produces alcohol inside the gut. Doctors tried to treat the man with a low-carb diet and antifungal medications, typically effective for this condition.

But it didn't help. The patient still experienced periodic, accidental drunkenness, in one case so severe that he lost his driving license after a random police check.

What finally did work was a poop transplant, according to a case study published August 18 in Annals of Internal Medicine.

Doctors were able to transfer the fecal microbiota, the bacteria present in poop, into the patient's small intestine. 34 months later, he continues to be symptom-free, according to the study.

The transplant was taken from the patient's 22-year-old daughter.

Researchers have theorized that overgrowth of fungus, specifically certain types of yeast, is behind the unusual phenomenon. Those fungi feed off of carbohydrates a person consumes and produce alcohol, just as yeast can feed off grains to produce beer outside the body.

In these cases, patients often become highly intoxicated from the alcohol in their digestive system, even though they haven't been drinking. In one extreme example, a man was found to have four times the legal limit of alcohol in his blood due to auto-brewery syndrome.

Since blood sugar levels fuel the yeast-driven booze production, diabetics and people with cirrhosis can be particularly susceptible to auto-brewery syndrome. So can people who have undergone digestive tract surgery, or who have recently completed a course of antibiotics, as both can disturb naturally-occurring gut microbes and create an imbalance.

That was true for this newest case study. In addition to having recently taken antibiotics, the patient also had a gastric bypass surgery years earlier.

A low-carb diet is sometimes effective in treating the syndrome
Typically, a low carb diet can help treat this syndrome, since fewer carbs in your system means less sugar for the yeast to convert to alcohol. An antifungal medication can also help tame the overgrown yeast.

In this case study, however, nearly two months of low-carb eating and four weeks of medication were apparently unsuccessful.

The study authors recommend that fecal transplants be considered in similar cases of auto-brewery syndrome. As the research on the transplants improves, they could one day be standard practice to treat this illness.

Read the original article on Insider
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