Brush your teeth! Gingivitis may be the cause of Alzheimer’s Disease

"Just floss people. And don't FORGET to floss. The more you floss, the less you will forget to floss. See how that works?"

-moehoward on Slashdot

 

I will just share that I've worked on this disease, dissecting out the hippocampus of pre-natal rats, and putting the neurons in culture. Never got anywhere. But pretty sure that if heaven is going to earmark cruelty to animals, I'm going down for dissecting all those brains. And let me just tell you, those brains are super small, and the dissection of the hippocampus, even smaller. Had to be done under a microscope. Ironically T-2 released the year I was doing this at Squibb. And even more ironic is that a high pressure water system nearly sank the lab that year. So much water you could canoe in it. And that's all I gotta say about that.

I changed my mind. Have one story to tell on this note. I wrote a short story called the ugly neuron, who turned into a beautiful schwann cell at college. Pretty damn clever right. I thought so too. But it was so cleaver they wanted make sure I didn't plaigerize it before going to print. I was kinda offended. And that's all I gotta say about that.

 

4 out of 5 dentists recommend blaming Alzheimer’s on not enough visits to their office, and not buying enough sugarless gum.

 

People used to try to link it to fluoride, ironically enough.

 

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Fluoride isn't a proven antimicrobial (although some debate it can have effects) so I'm not sure ironic the correct term.

High absorption of fluoride has been shown to be detrimental for your brain - https://www.hsph.harvard.edu/news/features/fluoride-childrens-health-grandjean-choi/


For the topic, interesting! Hope they are really on to something with the inhibitors.

 

Uh... I'm all for flossing, but this article is much more like a biotech press release than a journalist's coverage of a peer-reviewed breakthrough by conflict-free researchers.

And the chief scientific officer of the company announcing this is an MD. That's okay but do they even PhD, bro?

 

ApoE gene is where its at. Gene testing servces will test for it. The rate of Alzheimers by 75 is 3%. One copy of the e4 allele raises that to 6%. Two copies of e4 raises that to 28% according to the info I just pulled from 23andme. So two copies of the gene results in you being about 10x more likely to develop Alzheimer's than the average population. They obviously test for the gene, if you are concerned. I'm sure other gene testing services do too.

There's already a pretty strong correlation between gum disease and heart disease, I think, and heart disease is the number 1 cause of death in the US, so even if this is wrong, there is still plenty of reason to be concerned already.

 

All of these correlations are significant, but it seems too obvious to me. When it came to tobacco, everyone said there was no science, and there really wasn't, yet we all knew exactly what the canker at the root was. To me, sugar is the killer. What I think, is that all of this will be linked directly to sugar one day. But everyone's genetic reaction to sugar may differ. Same thing with Alcohol, we know what it does, but everyone's gene pool is slightly different in terms of whose brain is susceptible to permanent change.

 

They're on their way to phase 2,very interesting findings, would love to see further progress,Porphyromonas gingivalis (Pg) have been linked to
Rheumatoid arthritis (RA) which (is more likely)to increase the risk of developing Alzheimer's Disease (AD) & also associated with cardiovascular risk

 

This thread needs @rezdawg and his dental expertise.

 

There's no point of knowing ,more of a self inflicted psychological abuse even if its brca

 

Sometimes it might be worth knowing if there's a newer treatment plan/drugs that can be started ahead of a prion disease fully taking form. But I can see what you mean, with all of the research there still needs to be a lot better results (it's better than it used to be), but a lot more research needs to happen, and knowing ahead of time might not help at this point and it could make you worried etc. of something that might not even happen.

On brca, you don't think it's worth looking for, or do you think the patient is jumping too soon to treatments when there's no evidence of cancer forming? Like I know I've seen px's have a mastectomy ahead of time, but there's more sites brca could be an issue at etc. so it's not a perfect solution in some cases, especially if you have both copies and aren't planning on a proactive plan/testing (and have money to do so). Cancer sucks

 

Yeah, I have had initial hopes from promising research releases get ruined in the peer stages, hopefully this wasn't gamed and it does turn into something.

 

I think quality of life is more important than length of it, Eating healthy, exercise and avoiding stress ,etc, fits all and if there's any groundbreaking treatment ,it will be publicly known soon after

for the brca, I used it as a prime example of a useful genetic testing but progressively devastating as it involves the entire family ,facing the same fate but at different stages ,it might be applied to some a non surgical procedure with Tamoxin ,aromatase inhibitors,Raloxifene and SERM, and future generations of treatments
For BRCA pathogenic variant , surveillance with annual MRI which is way better than previous bilateral mastectomy only option

 

Yeah, that makes sense, quality of life for sure and especially less stress/healthy habits.

 

White people can tolerate sugar very well. Blacks and Hispanics not too well. But you are right, sugar is the new aids.