I actually thought Jevon Carter defended him well and had him out of his element. Not a big enough sample size as it was really a game or two, but he puts full court pressure on him and does a reasonable job staying in front of James.
I don't think there's an answer to that due to all the switching but also due to the fact he doesn't struggle against any one player per se but rather certain players give him small "fits" or annoy him at times though those times are rare. But the 2 most memorable defensive performances that comes to mind this year are Torrey Craig's game against Harden in FEB and Robert Covington in DEC. They gave him all sorts of fits and Covington actually looked like a dominant defender at times in the second half like a boxer deep into the rounds about to knock out his opponent after repeated body punches. He had that scary feel and aura that night even though Harden had a respectable game with 29 and 8 and shooting 47%.